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ShravyaRS/README.md

Shravya R S

Immunoinformatics | Computational Biology | Structural Bioinformatics

PhD Researcher · Immunomedicine Group · Universidad Complutense de Madrid

Email ORCID LinkedIn GitHub


About

Doctoral researcher in Biochemistry, Molecular Biology and Biomedicine at the Universidad Complutense de Madrid, working in the Immunomedicine Group on computational approaches to immune recognition.

My work sits where immunology meets large-scale sequence analysis: predicting and characterising T and B cell epitopes, comparing proteomes at scale, and building reproducible pipelines that turn raw sequence data into interpretable immunological results. I also have a background in structural bioinformatics and integrative structure model validation.

Previously: M.Sc. Bioinformatics, JSS Academy of Higher Education & Research, Mysuru.

Skills

Languages        Python, R, C, Bash/Linux, MATLAB
Immunoinformatics NetMHCpan, NetMHCIIpan, IEDB tools, BLAST+, epitope prediction,
                  HLA population coverage analysis
Structural Bio   Cryo-EM, mmCIF/PDB, PyMOL, ChimeraX, AlphaFold, NACCESS
ML / Data        scikit-learn, NumPy, SciPy, pandas, matplotlib
Bioinformatics   BioPython, sequence analysis, NGS, proteome-scale comparison
Tools            Git, GitHub Actions, Docker/Singularity, HPC

Research interests

  • Cross-reactive immunity and the sequence basis of immune recognition
  • Epitope prediction and vaccine target discovery
  • Integrative structure model validation
  • Reproducible pipelines for immunological and structural data

Open to collaborations in immunoinformatics, computational immunology, and structural bioinformatics.

Pinned Loading

  1. neoepitope-dna-repair neoepitope-dna-repair Public

    Shared missense neoepitopes across 29 DNA-repair genes in TCGA BRCA, COAD and OV - pipeline, analysis and figures. Accepted in Computational Biology and Chemistry (2026).

    Python 1

  2. IHMValidation-Analysis IHMValidation-Analysis Public

    Comprehensive technical analysis and exploration of IHMValidation software

    Python 1

  3. qscore-validation qscore-validation Public

    Q-score validation: Python (jamaliki/qscore) vs MapQ/Chimera

    Python 1

  4. IHMValidation IHMValidation Public

    Forked from salilab/IHMValidation

    Validation software for integrative models deposited to PDB

    Python

  5. qscore-mapq qscore-mapq Public

    Pure Python Q-score implementation matching MapQ (Pintilie et al. 2020). Validated on 28 EMDB entries: r = 0.999997. No Chimera dependency.

    Python

  6. molviewspec-validation molviewspec-validation Public

    MolViewSpec-based 3DEM validation visualization replacing ChimeraX

    Python 1