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<!DOCTYPE html>
<html lang="en">
<head>
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<meta charset="utf-8">
<meta name="author" content="Shelley Facente">
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<title>The Consortium for the Evaluation and Performance of HIV Incidence Assays (CEPHIA)</title>
</head>
<body>
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<div class="title" style="color:#ab3007"><h1>The Consortium for the Evaluation and Performance of HIV Incidence Assays (CEPHIA)</h1></div><br>
</nav>
<div class="content content-1">
<br>
<div class="title" style="color:#5175b0"><h4>Introduction and Overview</h4></div><br>
<div class="subtitle">The Consortium for the Evaluation and Performance of HIV Incidence Assays (CEPHIA) was formed in 2011, after members of an international Incidence Assay Critical Path Working Group meeting <a href="https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001045">identified a need</a> for cultivated HIV specimens to aid development of new HIV incidence assays. Following that meeting, the Bill and Melinda Gates Foundation provided funding to create CEPHIA to support the development of existing and new HIV incidence assays, improve data analysis and interpretation of incidence assay results, and bring consensus to the field. Importantly, the consortium was charged with creating a consolidated repository of over 30,000 highly-selected and well-characterized plasma specimens from around the world, along with setting standards and conducting independent evaluations of existing and new incidence assays, in order to remove real or perceived assay developer bias and allow direct, objective comparison of HIV incidence assays. A second round of funding (“CEPHIA 2”) in 2013 expanded the expensive repository of well-characterized plasma specimens to include prospectively collected serum, dried blood spots, urine, saliva, and stool.
More information about the work of CEPHIA during this phase is available <a href="https://www.cambridge.org/core/journals/epidemiology-and-infection/article/moving-towards-a-reliable-hiv-incidence-test-current-status-resources-available-future-directions-and-challenges-ahead/00CAA9784883BF7523D5F14F11BF35C7">here</a>, as well as in the Evaluation Reports and standard specimen panels detailed on this website.
<br><br>
CEPHIA is strengthened by its wide membership (see Membership, below), including close work with the World Health Organization/UNAIDS Technical
Working Group on HIV Incidence Measurement and Data Use. More information about CEPHIA and the need for centralized specimen archives can be found <a href="https://gatesopenresearch.org/articles/3-1511/v1">here</a>.
<!--- span style="color: #4D8AF0"><i>womp womp</i></span --->
</div>
<br><br><br>
</div>
<!-- Evaluation Reports -->
<div class="title" style="color:#5175b0"><h4>Evaluation Reports</h4></div><br>
<div class="subtitle">CEPHIA has conducted independent evaluations of 11 assays designed to assess recency of HIV infection (i.e. useful for estimating HIV incidence). The methods and findings of these evaluations are available in each of the Evaluation Reports (colloquially known as "blue books"), which can be accessed below:
<br><br>
<div class="subtitle"><a href="https://doi.org/10.5281/zenodo.3509841">Ortho Avidity-VITROS ECi</a></div>
<div class="subtitle"><a href="https://doi.org/10.5281/zenodo.3509853">Ortho Less Sensitive (LS)-VITROS ECi</a></div>
<div class="subtitle"><a href="https://doi.org/10.5281/zenodo.3509847">SEDIA™ BED HIV-1 Incidence EIA</a></div>
<div class="subtitle"><a href="https://doi.org/10.5281/zenodo.3509855">SEDIA™ HIV-1 LAg-Avidity EIA</a></div>
<div class="subtitle"><a href="https://doi.org/10.5281/zenodo.3509849">Bio-Rad GS HIV-1/HIV-2 PLUS O EIA Avidity Assay</a></div>
<div class="subtitle"><a href="https://doi.org/10.5281/zenodo.3509833">Asanté™ HIV-1 Rapid Recency® Assay</a></div>
<!--- br --->
<div class="subtitle"><!--- a href="" --->BioRad Geenius<!--- /a ---></div>
<!--- br --->
<div class="subtitle"><!--- a href="" --->Abbott Architect Avidity<!--- /a ---></div>
<!--- br --->
<div class="subtitle"><!--- a href="" --->Bio-Rad GS HIV-1/HIV-2 PLUS O EIA Avidity (Glasgow modification)<!--- /a ---></div>
<!--- br --->
<div class="subtitle"><!--- a href="" --->ANRS IDE-V3<!--- /a ---></div>
<!--- br --->
<div class="subtitle"><!--- a href="" --->Luminex (CDC multiplex)<!--- /a ---></div>
<br><br><br>
<!-- Available Panels -->
<div class="title" style="color:#5175b0"><h4>Available Panels</h4></div><br>
<div class=WordSection1>
<p class=MsoNormal style='margin-bottom:6.0pt;line-height:normal'><span
class=SpellE>All together</span>, CEPHIA has distributed over 50 panels of
well-characterized specimens to 19 investigators and groups since 2012. The table below provides more information about the five different panels available for access by external investigators, along with criteria for panel access. <b style='mso-bidi-font-weight:normal'><u><span
style='font-size:14.0pt;mso-no-proof:yes'><o:p></o:p></span></u></b></p>
<table class=MsoTableGrid width=100% border=1 cellspacing=0 cellpadding=0
style='border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
mso-yfti-tbllook:1184;mso-padding-alt:0in 5.4pt 0in 5.4pt'>
<tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'>
<td width=91 valign=top style='width:.95in;border:solid windowtext 1.0pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'>Category <o:p></o:p></b></p>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span
style='font-size:10.0pt;line-height:115%'><o:p> </o:p></span></b></p>
</td>
<td width=132 style='width:99.0pt;border:solid windowtext 1.0pt;border-left:
none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoNormal align=center style='text-align:center'><b
style='mso-bidi-font-weight:normal'>Discovery Panel (DP)<o:p></o:p></b></p>
<p class=MsoNormal align=center style='text-align:center'><b
style='mso-bidi-font-weight:normal'><o:p> </o:p></b></p>
</td>
<td width=132 style='width:99.0pt;border:solid windowtext 1.0pt;border-left:
none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoNormal align=center style='text-align:center'><b
style='mso-bidi-font-weight:normal'>Proof of Concept (POC)-Mean Duration of
Recent Infection (MDRI) panel<o:p></o:p></b></p>
</td>
<td width=126 style='width:94.5pt;border:solid windowtext 1.0pt;border-left:
none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoNormal align=center style='text-align:center'><b
style='mso-bidi-font-weight:normal'>POC-False Recent Ratio (FRR) panel<o:p></o:p></b></p>
<p class=MsoNormal align=center style='text-align:center'><b
style='mso-bidi-font-weight:normal'><o:p> </o:p></b></p>
</td>
<td width=168 style='width:1.75in;border:solid windowtext 1.0pt;border-left:
none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoNormal align=center style='text-align:center'><b
style='mso-bidi-font-weight:normal'>Qualification Panel (QP)<o:p></o:p></b></p>
</td>
<td width=84 style='width:63.0pt;border:solid windowtext 1.0pt;border-left:
none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoNormal align=center style='text-align:center'><b
style='mso-bidi-font-weight:normal'>Evaluation Panel (EP)<o:p></o:p></b></p>
</td>
</tr>
<tr style='mso-yfti-irow:1'>
<td width=91 valign=top style='width:.95in;border:solid windowtext 1.0pt;
border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span
style='font-size:10.0pt;line-height:115%'>Panel description<o:p></o:p></span></b></p>
</td>
<td width=132 valign=top style='width:99.0pt;border-top:none;border-left:
none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>50 specimens<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>15 recent, 35 non-recent<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Clade B <o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>All ARV naïve<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:9.0pt;line-height:115%'><o:p> </o:p></span></p>
</td>
<td width=132 valign=top style='width:99.0pt;border-top:none;border-left:
none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>100 specimens<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>All well-characterized estimated infection date<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>50 0-12 months from infection<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>50 12-24 months from infection<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Mixed Clade<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>All ARV naïve<o:p></o:p></span></p>
</td>
<td width=126 valign=top style='width:94.5pt;border-top:none;border-left:
none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>150 specimens<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>All >2 years from HIV infection date<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Mixed Clade<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>All ARV naïve<o:p></o:p></span></p>
</td>
<td width=168 valign=top style='width:1.75in;border-top:none;border-left:
none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>250 specimens<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>50 recent (including 5 series of 5 specimens each)<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>125 non-recent<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>12 elite <span class=GramE>controller</span><o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>13 ART-suppressed<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>50 reproducibility (10 blood donor specimens included as 5
replicates each)<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>All Clade B<o:p></o:p></span></p>
</td>
<td width=84 valign=top style='width:63.0pt;border-top:none;border-left:none;
border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>3000 specimens<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>5 panels of 485 unique specimens and 15 controls<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>All blood plasma<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Always blinded<o:p></o:p></span></p>
</td>
</tr>
<tr style='mso-yfti-irow:2;mso-yfti-lastrow:yes'>
<td width=91 valign=top style='width:.95in;border:solid windowtext 1.0pt;
border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span
style='font-size:10.0pt;line-height:115%'>Criteria for panel access<o:p></o:p></span></b></p>
</td>
<td width=132 valign=top style='width:99.0pt;border-top:none;border-left:
none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Plausible concept<o:p></o:p></span></p>
</td>
<td width=132 valign=top style='width:99.0pt;border-top:none;border-left:
none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Associated with HIV<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Associated with recency<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Can be reliably measured, tunable threshold <o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Useful as classifier<o:p></o:p></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>MDRI analysis plan approved by SACEMA<o:p></o:p></span></p>
</td>
<td width=126 valign=top style='width:94.5pt;border-top:none;border-left:
none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Threshold with plausible MDRI (4-24mo)<b style='mso-bidi-font-weight:
normal'><o:p></o:p></b></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>FRR analysis plan approved by SACEMA<b style='mso-bidi-font-weight:
normal'><o:p></o:p></b></span></p>
</td>
<td width=168 valign=top style='width:1.75in;border-top:none;border-left:
none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Threshold with plausible MDRI (4-24mo)<b style='mso-bidi-font-weight:
normal'><o:p></o:p></b></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Threshold with plausible FRR (<15%)<b style='mso-bidi-font-weight:
normal'><o:p></o:p></b></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Consistent FRR between clades<b style='mso-bidi-font-weight:
normal'><o:p></o:p></b></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Final protocol with proposed threshold<b style='mso-bidi-font-weight:
normal'><o:p></o:p></b></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>Potential advantages<b style='mso-bidi-font-weight:normal'><o:p></o:p></b></span></p>
</td>
<td width=84 valign=top style='width:63.0pt;border-top:none;border-left:none;
border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
mso-border-alt:solid windowtext .5pt;padding:0in 5.4pt 0in 5.4pt'>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>MDRI 4-24mo<b style='mso-bidi-font-weight:normal'><o:p></o:p></b></span></p>
<p class=MsoListParagraph style='margin-left:9.0pt;mso-add-space:auto;
text-indent:-9.0pt;mso-list:l0 level1 lfo1'><![if !supportLists]><span
style='font-size:9.0pt;font-family:"Calibri",sans-serif;mso-fareast-font-family:
Calibri'><span style='mso-list:Ignore'>-<span style='font:7.0pt "Times New Roman"'>
</span></span></span><![endif]><span style='font-size:9.0pt;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:
"Times New Roman"'>FRR not inferior to BED-CEIA<b style='mso-bidi-font-weight:
normal'><o:p></o:p></b></span></p>
</td>
</tr>
</table>
<br>
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<div class="title" style="color:#5175b0"><h4>Request Panel Access:</h4></div>If you would like to request access to one of the CEPHIA panels listed above, complete <a href="/assets/CEPHIA_requestform.docx">this request form</a> and email it to us at sfacente [at] vitalant.org. Someone will be in touch with you shortly about your request.<br>
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<div class="title" style="color:#5175b0"><h4>Consortium Members</h4></div><br>
CEPHIA is staffed by the following core members:<br><br>
<ul>
• <b>Alex Welte</b>, <b>Joseph Sempa</b>, formerly: David Matten, Hilmarié Brand, Trust Chibawara (South African Centre for Epidemiological Modelling and Analysis, Stellenbosch University)<br>
• <b>Gary Murphy</b>, <b>Jake Hall</b>, formerly: Elaine Mckinney (Public Health England)<br>
• <b>Michael P. Busch</b>, <b>Eduard Grebe</b>, <b>Shelley Facente</b>, formerly: Sheila Keating, Dylan Hampton, Mila Lebedeva (Vitalant Research Institute)<br>
• <b>Christopher D. Pilcher</b>, formerly: Kara Marson (University of California San Francisco)<br></ul>
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Other members of CEPHIA include outstanding researchers from around the globe, including:<br><br>
<ul>
• Reshma Kassanjee (University of Cape Town)<br>
• Oliver Laeyendecker, Thomas Quinn, David Burns (National Institutes of Health)<br>
• Susan Little (University of California San Diego)<br>
• Anita Sands (World Health Organization)<br>
• Tim Hallett (Imperial College London)<br>
• S. Michele Owen, Bharat Parekh, Connie Sexton (Centers for Disease Control and Prevention)<br>
• Matthew Price, Anatoli Kamali (International AIDS Vaccine Initiative)<br>
• Lisa Loeb (formerly of The Options Study - University of California San Francisco)<br>
• Jeffrey Martin, Steven Deeks, Rebecca Hoh (The SCOPE Study – University of California San Francisco)<br>
• Zelinda Bartolomei, Natalia Cerqueira (The AMPLIAR Cohort – University of São Paulo)<br>
• Breno Santos, Kellin Zabtoski, Rita de Cassia Alves Lira (The AMPLIAR Cohort Grupo Hospital Conceição)<br>
• Rosa Dea Sperhacke, Leonardo R Motta, Machline Paganella (The AMPLIAR Cohort – Universidade Caxias Do Sul)<br>
• Esper Kallas, Helena Tomiyama, Claudia Tomiyama, Priscilla Costa, Maria A Nunes, Gisele Reis, Mariana M Sauer, Natalia Cerqueira, Zelinda Nakagawa,<br> Lilian Ferrari, Ana P Amaral, Karine Milani (The São Paulo Cohort University of São Paulo, Brazil)<br>
• Salim S Abdool Karim, Quarraisha Abdool Karim, Thumbi Ndungu, Nelisile Majola, Natasha Samsunder (CAPRISA, University of Kwazulu-Natal)<br>
• Denise Naniche (The GAMA Study – Barcelona Centre for International Health Research)<br>
• Inácio Mandomando, Eusebio V Macete (The GAMA Study – Fundacao Manhica)<br>
• Jorge Sanchez, Javier Lama (SABES Cohort – Asociación Civil Impacta Salud y Educación (IMPACTA))<br>
• Ann Duerr (The Fred Hutchinson Cancer Research Center)<br>
• Maria R Capobianchi (National Institute for Infectious Diseases “L. Spallanzani”, Rome)<br>
• Barbara Suligoi (Istituto Superiore di Sanità, Rome)<br>
• Susan Stramer (American Red Cross)<br>
• Phillip Williamson (Creative Testing Solutions / Vitalant Research Institute); <br>
• Marion Vermeulen (South African National Blood Service)<br>
• Ester Sabino (Hemocentro do São Paolo)<br>
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