From 9bce4f56ae59e09122996ee5aceb1ddeba5cd14a Mon Sep 17 00:00:00 2001 From: Cursor Agent Date: Fri, 3 Apr 2026 23:10:41 +0000 Subject: [PATCH] Add data extraction for Article 1: Cistus incanus (CYSTUS052) clinical study Co-authored-by: Matheus Frigo --- Article_1_Data_Extraction.md | 65 ++++++++++++++++++++++++++++++++++++ 1 file changed, 65 insertions(+) create mode 100644 Article_1_Data_Extraction.md diff --git a/Article_1_Data_Extraction.md b/Article_1_Data_Extraction.md new file mode 100644 index 0000000..4719c68 --- /dev/null +++ b/Article_1_Data_Extraction.md @@ -0,0 +1,65 @@ +# Data Extraction — Article 1 + +## Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract + +--- + +## 1. General Information + +| Item | Extracted Data | +|---|---| +| **Year** | 2009 | +| **Journal** | Antiviral Research | +| **Authorship** | National (all authors from Germany) | +| **Funding / Financial Support** | Not have | +| **Study Type** | Clinical Trial | + +### Abstract + +In this prospective, randomized, placebo-controlled clinical study we aimed to investigate the clinical effect of a Cistus extract (CYSTUS052) in 160 patients with infections of the upper respiratory tract. The extract contains a high percentage of highly polymeric polyphenols. In cell culture and in a mouse model it exerts antiviral and antimicrobial activities. Principal active constituents of the genus Cistus are polyphenolic compounds. Plant-derived polyphenols have been shown to be strong antioxidants with potential health benefits. Various reports have appeared on the antiviral and antibacterial potential, including several reports describing the antiviral activity of polyphenols against influenza virus. Clinical studies on the effectiveness of Cistus incanus are scarce. Only one controlled application observation study demonstrated the effectiveness of a Cistus extract. The present randomised, placebo-controlled clinical study was designed to compare the symptom scores in patients with common cold treated either with CYSTUS052 or with placebo. A score of subjective symptoms decreased significantly over the course of treatment with Cistus, whereas treatment with placebo resulted in a less distinct decrease of symptoms. Among the inflammatory markers investigated, the C-reactive protein was mostly affected by Cistus and decreased significantly in the treatment group. + +--- + +## 2. Authors, Affiliations, and Country + +| Author | Affiliation | Country | +|---|---|---| +| Ulrich Kalus | Institut für Transfusionsmedizin, Charité - Universitaetsmedizin Berlin, Campus Charité Mitte, D-10098 Berlin | Germany | +| Alexandre Grigorov | Institut für Transfusionsmedizin, Charité - Universitaetsmedizin Berlin, Campus Charité Mitte, D-10098 Berlin | Germany | +| Oliver Kadecki | Medical Praxis for General Medicine, General Practitioner, Trebbin | Germany | +| Jan-Peter Jansen | Medical Center for Anaesthesiology, Berlin | Germany | +| Holger Kiesewetter | Institut für Transfusionsmedizin, Charité - Universitaetsmedizin Berlin, Campus Charité Mitte, D-10098 Berlin | Germany | +| Hartmut Radtke | Institut für Transfusionsmedizin, Charité - Universitaetsmedizin Berlin, Campus Charité Mitte, D-10098 Berlin | Germany | + +--- + +## 3. Keywords + +| Keywords | +|---| +| Cistus incanus | +| CYSTUS052 | +| Infection of the upper respiratory tract | +| Score of subjective symptoms | + +--- + +## 4. Plants Information + +| Species | Family | Plant Part | Extraction | +|---|---|---|---| +| Cistus incanus | Cistaceae | Not have | Not have | + +--- + +## 5. Bacteria Information + +| Pathogens | ATCC | Isolates Uses | +|---|---|---| +| Staphylococcus aureus | Not have | Clinical isolates from throat-swabs taken from patients and subjected to a suitable bacterial culture medium regarding the pathogen of the infection | +| Streptococcus pneumoniae | Not have | Clinical isolates from throat-swabs taken from patients and subjected to a suitable bacterial culture medium regarding the pathogen of the infection | +| Mycoplasma pneumoniae | Not have | Clinical isolates from throat-swabs taken from patients and subjected to a suitable bacterial culture medium regarding the pathogen of the infection | +| Chlamydia pneumonia | Not have | Clinical isolates from throat-swabs taken from patients and subjected to a suitable bacterial culture medium regarding the pathogen of the infection | +| Haemophilus influenzae | Not have | Clinical isolates from throat-swabs taken from patients and subjected to a suitable bacterial culture medium regarding the pathogen of the infection | +| Influenza A Virus | Not have | Clinical isolates identified by a rapid test for the differentiated detection of Influenza A and B (BioStar OIA FLU A/B, Inverness Medical) | +| Influenza B Virus | Not have | Clinical isolates identified by a rapid test for the differentiated detection of Influenza A and B (BioStar OIA FLU A/B, Inverness Medical) |