diff --git a/middleware/cors.go b/middleware/cors.go
index 96ed16985..d7e8d5446 100644
--- a/middleware/cors.go
+++ b/middleware/cors.go
@@ -193,7 +193,25 @@ func (config CORSConfig) ToMiddleware() (echo.MiddlewareFunc, error) {
 			res := c.Response()
 			origin := req.Header.Get(echo.HeaderOrigin)
 
-			res.Header().Add(echo.HeaderVary, echo.HeaderOrigin)
+			// Check if CORS headers already exist (e.g., from a proxied upstream service)
+			// to avoid duplication in proxy chains
+			if res.Header().Get(echo.HeaderAccessControlAllowOrigin) != "" {
+				// CORS headers already present, likely from upstream - skip processing
+				if preflight := req.Method == http.MethodOptions; preflight {
+					return c.NoContent(http.StatusNoContent)
+				}
+				return next(c)
+			}
+
+			// Add Origin to Vary header only if not already present
+			varyHeader := res.Header().Get(echo.HeaderVary)
+			if !strings.Contains(varyHeader, echo.HeaderOrigin) {
+				if varyHeader == "" {
+					res.Header().Set(echo.HeaderVary, echo.HeaderOrigin)
+				} else {
+					res.Header().Set(echo.HeaderVary, varyHeader+", "+echo.HeaderOrigin)
+				}
+			}
 
 			// Preflight request is an OPTIONS request, using three HTTP request headers: Access-Control-Request-Method,
 			// Access-Control-Request-Headers, and the Origin header. See: https://developer.mozilla.org/en-US/docs/Glossary/Preflight_request
@@ -261,8 +279,20 @@ func (config CORSConfig) ToMiddleware() (echo.MiddlewareFunc, error) {
 			// Preflight will end with c.NoContent(http.StatusNoContent) as we do not know if
 			// at the end of handler chain is actual OPTIONS route or 404/405 route which
 			// response code will confuse browsers
-			res.Header().Add(echo.HeaderVary, echo.HeaderAccessControlRequestMethod)
-			res.Header().Add(echo.HeaderVary, echo.HeaderAccessControlRequestHeaders)
+
+			// Add to Vary header only if not already present
+			varyHeader = res.Header().Get(echo.HeaderVary)
+			varyValues := []string{echo.HeaderAccessControlRequestMethod, echo.HeaderAccessControlRequestHeaders}
+			for _, varyValue := range varyValues {
+				if !strings.Contains(varyHeader, varyValue) {
+					if varyHeader == "" {
+						varyHeader = varyValue
+					} else {
+						varyHeader = varyHeader + ", " + varyValue
+					}
+				}
+			}
+			res.Header().Set(echo.HeaderVary, varyHeader)
 
 			if !hasCustomAllowMethods && routerAllowMethods != "" {
 				res.Header().Set(echo.HeaderAccessControlAllowMethods, routerAllowMethods)
diff --git a/middleware/cors_test.go b/middleware/cors_test.go
index 5de4ca063..91034afa4 100644
--- a/middleware/cors_test.go
+++ b/middleware/cors_test.go
@@ -626,3 +626,83 @@ func Test_allowOriginFunc(t *testing.T) {
 		}
 	}
 }
+
+// TestCORSProxyChain tests that CORS headers are not duplicated when
+// multiple CORS middlewares are chained in a proxy scenario
+func TestCORSProxyChain(t *testing.T) {
+	e := echo.New()
+	req := httptest.NewRequest(http.MethodGet, "/", nil)
+	req.Header.Set(echo.HeaderOrigin, "http://example.com")
+	rec := httptest.NewRecorder()
+	c := e.NewContext(req, rec)
+
+	// Simulate Service B (upstream) that already set CORS headers
+	upstreamHandler := func(c *echo.Context) error {
+		c.Response().Header().Set(echo.HeaderAccessControlAllowOrigin, "http://example.com")
+		c.Response().Header().Set(echo.HeaderVary, "Origin")
+		return c.String(http.StatusOK, "test")
+	}
+
+	// Apply CORS middleware on Service A (proxy layer)
+	mw := CORS("*")
+	handler := mw(upstreamHandler)
+
+	err := handler(c)
+	assert.NoError(t, err)
+	assert.Equal(t, http.StatusOK, rec.Code)
+
+	// Verify headers are not duplicated
+	assert.Equal(t, "http://example.com", rec.Header().Get(echo.HeaderAccessControlAllowOrigin))
+	
+	// Check that Vary header contains "Origin" only once
+	varyHeader := rec.Header().Get(echo.HeaderVary)
+	assert.Contains(t, varyHeader, "Origin")
+	
+	// Count occurrences of "Origin" in Vary header - should be exactly 1
+	originCount := strings.Count(varyHeader, "Origin")
+	assert.Equal(t, 1, originCount, "Vary header should contain 'Origin' only once, got: %s", varyHeader)
+
+	// Verify there's no duplicate Access-Control-Allow-Origin header
+	allowOriginHeaders := rec.Header().Values(echo.HeaderAccessControlAllowOrigin)
+	assert.Equal(t, 1, len(allowOriginHeaders), "Should have exactly one Access-Control-Allow-Origin header")
+}
+
+// TestCORSProxyChainPreflight tests preflight requests in proxy chains
+func TestCORSProxyChainPreflight(t *testing.T) {
+	e := echo.New()
+	req := httptest.NewRequest(http.MethodOptions, "/", nil)
+	req.Header.Set(echo.HeaderOrigin, "http://example.com")
+	req.Header.Set(echo.HeaderAccessControlRequestMethod, "POST")
+	rec := httptest.NewRecorder()
+	c := e.NewContext(req, rec)
+
+	// Simulate Service B (upstream) that already set CORS headers
+	upstreamHandler := func(c *echo.Context) error {
+		c.Response().Header().Set(echo.HeaderAccessControlAllowOrigin, "*")
+		c.Response().Header().Set(echo.HeaderVary, "Origin, Access-Control-Request-Method, Access-Control-Request-Headers")
+		c.Response().Header().Set(echo.HeaderAccessControlAllowMethods, "GET,POST,PUT")
+		return c.NoContent(http.StatusNoContent)
+	}
+
+	// Apply CORS middleware on Service A (proxy layer)
+	mw := CORS("*")
+	handler := mw(upstreamHandler)
+
+	err := handler(c)
+	assert.NoError(t, err)
+	assert.Equal(t, http.StatusNoContent, rec.Code)
+
+	// Verify headers are not duplicated
+	assert.Equal(t, "*", rec.Header().Get(echo.HeaderAccessControlAllowOrigin))
+	
+	// Check that Vary header contains each value only once
+	varyHeader := rec.Header().Get(echo.HeaderVary)
+	assert.Contains(t, varyHeader, "Origin")
+	
+	originCount := strings.Count(varyHeader, "Origin")
+	assert.Equal(t, 1, originCount, "Vary header should contain 'Origin' only once, got: %s", varyHeader)
+
+	// Verify there's no duplicate Access-Control-Allow-Origin header
+	allowOriginHeaders := rec.Header().Values(echo.HeaderAccessControlAllowOrigin)
+	assert.Equal(t, 1, len(allowOriginHeaders), "Should have exactly one Access-Control-Allow-Origin header")
+}