diff --git a/packages/google-auth/setup.py b/packages/google-auth/setup.py
index cff8a7bdbda9..6e3463f99233 100644
--- a/packages/google-auth/setup.py
+++ b/packages/google-auth/setup.py
@@ -18,8 +18,8 @@
 from setuptools import find_namespace_packages, setup
 
 cryptography_base_require = [
-    "cryptography >= 38.0.3; python_version < '3.14'",
-    "cryptography >= 41.0.5; python_version >= '3.14'",
+    "cryptography >= 46.0.5; python_version < '3.14'",
+    "cryptography >= 50.0.1; python_version >= '3.14'",
 ]
 
 DEPENDENCIES = (
diff --git a/packages/google-auth/testing/constraints-3.10.txt b/packages/google-auth/testing/constraints-3.10.txt
index f9467d86a690..d70a7e8723c4 100644
--- a/packages/google-auth/testing/constraints-3.10.txt
+++ b/packages/google-auth/testing/constraints-3.10.txt
@@ -7,7 +7,7 @@
 # Then this file should have foo==1.14.0
 pyasn1-modules==0.2.1
 setuptools==40.3.0
-cryptography==38.0.3
+cryptography==46.0.5
 aiohttp==3.8.0
 requests==2.30.0
 pyjwt==2.0
diff --git a/packages/google-auth/testing/constraints-3.14.txt b/packages/google-auth/testing/constraints-3.14.txt
index 64212e65e4df..2590a2cfbec2 100644
--- a/packages/google-auth/testing/constraints-3.14.txt
+++ b/packages/google-auth/testing/constraints-3.14.txt
@@ -6,5 +6,5 @@
 # e.g., if setup.py has "foo >= 1.14.0, < 2.0.0dev",
 # Then this file should have foo==1.14.0
 pyasn1-modules==0.2.1
-cryptography==41.0.5
+cryptography==50.0.1
 aiohttp==3.9.0