diff --git a/.golangci.yml b/.golangci.yml
index a2fea56937c..e3537546387 100644
--- a/.golangci.yml
+++ b/.golangci.yml
@@ -228,6 +228,7 @@ linters:
             - HookResponse.RawPayload
             - Issue.PullRequestLinks # TODO: PullRequest
             - IssueImportRequest.IssueImport # TODO: Issue
+            - IssueListByRepoOptions.ExcludeLabels # url:"-" skips query param; no matching tag
             - IssuesSearchResult.Issues # TODO: Items
             - IssuesSearchResult.Total
             - LabelsSearchResult.Labels # TODO: Items
diff --git a/github/github-accessors.go b/github/github-accessors.go
index bc3194bc1b6..29c68fc8518 100644
--- a/github/github-accessors.go
+++ b/github/github-accessors.go
@@ -20078,6 +20078,14 @@ func (i *IssueListByRepoOptions) GetDirection() string {
 	return i.Direction
 }
 
+// GetExcludeLabels returns the ExcludeLabels slice if it's non-nil, nil otherwise.
+func (i *IssueListByRepoOptions) GetExcludeLabels() []string {
+	if i == nil || i.ExcludeLabels == nil {
+		return nil
+	}
+	return i.ExcludeLabels
+}
+
 // GetLabels returns the Labels slice if it's non-nil, nil otherwise.
 func (i *IssueListByRepoOptions) GetLabels() []string {
 	if i == nil || i.Labels == nil {
diff --git a/github/github-accessors_test.go b/github/github-accessors_test.go
index c9ced173fe0..b944266f2b7 100644
--- a/github/github-accessors_test.go
+++ b/github/github-accessors_test.go
@@ -25392,6 +25392,17 @@ func TestIssueListByRepoOptions_GetDirection(tt *testing.T) {
 	i.GetDirection()
 }
 
+func TestIssueListByRepoOptions_GetExcludeLabels(tt *testing.T) {
+	tt.Parallel()
+	zeroValue := []string{}
+	i := &IssueListByRepoOptions{ExcludeLabels: zeroValue}
+	i.GetExcludeLabels()
+	i = &IssueListByRepoOptions{}
+	i.GetExcludeLabels()
+	i = nil
+	i.GetExcludeLabels()
+}
+
 func TestIssueListByRepoOptions_GetLabels(tt *testing.T) {
 	tt.Parallel()
 	zeroValue := []string{}
diff --git a/github/issues.go b/github/issues.go
index bea89912b5a..28fe4c01e84 100644
--- a/github/issues.go
+++ b/github/issues.go
@@ -8,6 +8,7 @@ package github
 import (
 	"context"
 	"fmt"
+	"strings"
 	"time"
 )
 
@@ -364,6 +365,11 @@ type IssueListByRepoOptions struct {
 	// Labels filters issues based on their label.
 	Labels []string `url:"labels,omitempty,comma"`
 
+	// ExcludeLabels filters issues to exclude those with the specified labels.
+	// Filtering is done client-side after fetching, since GitHub's Issues REST API
+	// does not support server-side label exclusion.
+	ExcludeLabels []string `url:"-"`
+
 	// Sort specifies how to sort issues. Possible values are: created, updated,
 	// and comments. Default value is "created".
 	Sort string `url:"sort,omitempty"`
@@ -408,6 +414,30 @@ func (s *IssuesService) ListByRepo(ctx context.Context, owner, repo string, opts
 		return nil, resp, err
 	}
 
+	// Filter out issues with excluded labels client-side.
+	// The GitHub Issues REST API does not support server-side label exclusion,
+	// so we apply the filter in-memory after fetching results.
+	if len(opts.ExcludeLabels) > 0 {
+		exclude := make(map[string]bool, len(opts.ExcludeLabels))
+		for _, l := range opts.ExcludeLabels {
+			exclude[strings.ToLower(l)] = true
+		}
+		filtered := make([]*Issue, 0, len(issues))
+		for _, issue := range issues {
+			shouldExclude := false
+			for _, label := range issue.Labels {
+				if exclude[strings.ToLower(label.GetName())] {
+					shouldExclude = true
+					break
+				}
+			}
+			if !shouldExclude {
+				filtered = append(filtered, issue)
+			}
+		}
+		issues = filtered
+	}
+
 	return issues, resp, nil
 }
 
diff --git a/github/issues_test.go b/github/issues_test.go
index e4da6c72c49..fe386db42ec 100644
--- a/github/issues_test.go
+++ b/github/issues_test.go
@@ -192,8 +192,8 @@ func TestIssuesService_ListByRepo(t *testing.T) {
 			"assignee":  "a",
 			"creator":   "c",
 			"mentioned": "m",
-			"labels":    "a,b",
-			"sort":      "updated",
+		"labels":    "a,b",
+		"sort":      "updated",
 			"direction": "asc",
 			"since":     referenceTime.Format(time.RFC3339),
 			"per_page":  "1",
@@ -209,6 +209,7 @@ func TestIssuesService_ListByRepo(t *testing.T) {
 		Creator:           "c",
 		Mentioned:         "m",
 		Labels:            []string{"a", "b"},
+		ExcludeLabels:     []string{"c", "d"},
 		Sort:              "updated",
 		Direction:         "asc",
 		Since:             referenceTime,
@@ -241,6 +242,47 @@ func TestIssuesService_ListByRepo(t *testing.T) {
 	})
 }
 
+func TestIssuesService_ListByRepo_ExcludeLabels(t *testing.T) {
+	t.Parallel()
+	client, mux, _ := setup(t)
+
+	mux.HandleFunc("/repos/o/r/issues", func(w http.ResponseWriter, r *http.Request) {
+		testMethod(t, r, "GET")
+		testHeader(t, r, "Accept", mediaTypeReactionsPreview)
+		// ExcludeLabels should NOT be sent as a query parameter.
+		testFormValues(t, r, values{
+			"labels": "bug",
+		})
+		// Server returns all bug-labeled issues; client-side filtering handles exclusion.
+		fmt.Fprint(w, `[
+			{"number":1, "labels":[{"name":"bug"}]},
+			{"number":2, "labels":[{"name":"bug"},{"name":"wontfix"}]},
+			{"number":3, "labels":[{"name":"bug"},{"name":"enhancement"}]},
+			{"number":4, "labels":[{"name":"bug"},{"name":"wontfix"},{"name":"duplicate"}]}
+		]`)
+	})
+
+	opt := &IssueListByRepoOptions{
+		Labels:        []string{"bug"},
+		ExcludeLabels: []string{"wontfix", "duplicate"},
+	}
+
+	ctx := t.Context()
+	issues, _, err := client.Issues.ListByRepo(ctx, "o", "r", opt)
+	if err != nil {
+		t.Errorf("Issues.ListByRepo returned error: %v", err)
+	}
+
+	// Issues #1 and #3 should remain; #2 and #4 should be excluded by client-side filter.
+	want := []*Issue{
+		{Number: Ptr(1), Labels: []*Label{{Name: Ptr("bug")}}},
+		{Number: Ptr(3), Labels: []*Label{{Name: Ptr("bug")}, {Name: Ptr("enhancement")}}},
+	}
+	if !cmp.Equal(issues, want) {
+		t.Errorf("Issues.ListByRepo returned %+v, want %+v", issues, want)
+	}
+}
+
 func TestIssuesService_Get(t *testing.T) {
 	t.Parallel()
 	client, mux, _ := setup(t)