diff --git a/CHANGELOG.md b/CHANGELOG.md
index 87274d1c1a..d909cf1d6e 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -11,6 +11,7 @@
 ### Features
 
 - Add experimental `enableStandaloneAppStartTracing` to send app start as a standalone `app.start` transaction ([#6359](https://github.com/getsentry/sentry-react-native/pull/6359))
+- Set `app.vitals.start.screen` on the standalone `app.start` transaction from the current route ([#6369](https://github.com/getsentry/sentry-react-native/pull/6369))
 - Add `enableTurboModuleTracking` opt-in experimental option to enable Turbo Module performance tracking in the New Architecture ([#6307](https://github.com/getsentry/sentry-react-native/pull/6307))
 - Use the runtime's native `btoa` for envelope base64 encoding when available, to improve `captureEnvelope` performance. Falls back to the bundled JS encoder if `btoa` is missing ([#6351](https://github.com/getsentry/sentry-react-native/pull/6351)).
 - Opt-in build-time auto-wrap for Expo Router's per-route `ErrorBoundary` ([#6347](https://github.com/getsentry/sentry-react-native/pull/6347))
diff --git a/packages/core/src/js/tracing/integrations/appStart.ts b/packages/core/src/js/tracing/integrations/appStart.ts
index c628fa279e..79c2c0f79b 100644
--- a/packages/core/src/js/tracing/integrations/appStart.ts
+++ b/packages/core/src/js/tracing/integrations/appStart.ts
@@ -31,7 +31,9 @@ import {
   UI_LOAD as UI_LOAD_OP,
 } from '../ops';
 import { SPAN_ORIGIN_AUTO_APP_START, SPAN_ORIGIN_MANUAL_APP_START } from '../origin';
+import { getCurrentReactNativeTracingIntegration } from '../reactnativetracing';
 import {
+  SEMANTIC_ATTRIBUTE_APP_VITALS_START_SCREEN,
   SEMANTIC_ATTRIBUTE_APP_VITALS_START_TYPE,
   SEMANTIC_ATTRIBUTE_APP_VITALS_START_VALUE,
   SEMANTIC_ATTRIBUTE_SENTRY_OP,
@@ -659,6 +661,15 @@ export const appStartIntegration = ({
       event.contexts.trace.data[SEMANTIC_ATTRIBUTE_APP_VITALS_START_VALUE] = appStartDurationMs;
       event.contexts.trace.data[SEMANTIC_ATTRIBUTE_APP_VITALS_START_TYPE] = appStart.type;
 
+      // Screen shown when app start completes. Unlike the non-standalone `ui.load` transaction
+      // (whose name is the screen, which Relay backfills from), the standalone transaction is named
+      // `App Start`, so we set the screen explicitly. Sourced from the current route tracked by the
+      // tracing integration; omitted when no route has been registered yet at capture time.
+      const screen = getCurrentReactNativeTracingIntegration()?.state.currentRoute;
+      if (screen) {
+        event.contexts.trace.data[SEMANTIC_ATTRIBUTE_APP_VITALS_START_SCREEN] = screen;
+      }
+
       // Minimal parent referencing the root transaction span, so the breakdown spans attach
       // directly under it (the helpers only read op/origin/span_id/trace_id/start_timestamp).
       // `data` is shared with the root trace context so frame data lands on the root span.
diff --git a/packages/core/src/js/tracing/semanticAttributes.ts b/packages/core/src/js/tracing/semanticAttributes.ts
index ab8f033000..1e7d3b4474 100644
--- a/packages/core/src/js/tracing/semanticAttributes.ts
+++ b/packages/core/src/js/tracing/semanticAttributes.ts
@@ -22,3 +22,4 @@ export const SEMANTIC_ATTRIBUTE_NAVIGATION_ACTION_TYPE = 'navigation.action_type
 // App start vitals (Span V2 / EAP). Emitted on the standalone `app.start` transaction.
 export const SEMANTIC_ATTRIBUTE_APP_VITALS_START_VALUE = 'app.vitals.start.value';
 export const SEMANTIC_ATTRIBUTE_APP_VITALS_START_TYPE = 'app.vitals.start.type';
+export const SEMANTIC_ATTRIBUTE_APP_VITALS_START_SCREEN = 'app.vitals.start.screen';
diff --git a/packages/core/test/tracing/integrations/appStart.test.ts b/packages/core/test/tracing/integrations/appStart.test.ts
index 9baf5be660..9f3f7661ef 100644
--- a/packages/core/test/tracing/integrations/appStart.test.ts
+++ b/packages/core/test/tracing/integrations/appStart.test.ts
@@ -36,7 +36,9 @@ import {
   setRootComponentCreationTimestampMs,
 } from '../../../src/js/tracing/integrations/appStart';
 import { SPAN_ORIGIN_AUTO_APP_START, SPAN_ORIGIN_MANUAL_APP_START } from '../../../src/js/tracing/origin';
+import * as ReactNativeTracing from '../../../src/js/tracing/reactnativetracing';
 import {
+  SEMANTIC_ATTRIBUTE_APP_VITALS_START_SCREEN,
   SEMANTIC_ATTRIBUTE_APP_VITALS_START_TYPE,
   SEMANTIC_ATTRIBUTE_APP_VITALS_START_VALUE,
 } from '../../../src/js/tracing/semanticAttributes';
@@ -147,6 +149,32 @@ describe('App Start Integration', () => {
       });
     });
 
+    it('sets app.vitals.start.screen from the current route', async () => {
+      const [timeOriginMilliseconds, appStartTimeMilliseconds] = mockAppStart({ cold: true });
+      const screenSpy = jest
+        .spyOn(ReactNativeTracing, 'getCurrentReactNativeTracingIntegration')
+        .mockReturnValue({ state: { currentRoute: 'HomeScreen' } } as ReturnType<
+          typeof ReactNativeTracing.getCurrentReactNativeTracingIntegration
+        >);
+
+      try {
+        const actualEvent = await captureStandAloneAppStart();
+        expect(actualEvent).toEqual(
+          expectEventWithStandaloneColdAppStart(actualEvent, { timeOriginMilliseconds, appStartTimeMilliseconds }),
+        );
+        expect(actualEvent?.contexts?.trace?.data?.[SEMANTIC_ATTRIBUTE_APP_VITALS_START_SCREEN]).toBe('HomeScreen');
+      } finally {
+        screenSpy.mockRestore();
+      }
+    });
+
+    it('omits app.vitals.start.screen when no route has been registered', async () => {
+      mockAppStart({ cold: true });
+
+      const actualEvent = await captureStandAloneAppStart();
+      expect(actualEvent?.contexts?.trace?.data).not.toHaveProperty(SEMANTIC_ATTRIBUTE_APP_VITALS_START_SCREEN);
+    });
+
     it('Does not add any spans or measurements when App Start Span is longer than threshold', async () => {
       set__DEV__(false);
       mockTooLongAppStart();