diff --git a/tools/system_libs.py b/tools/system_libs.py
index 9d082585abed9..254ef063a1376 100644
--- a/tools/system_libs.py
+++ b/tools/system_libs.py
@@ -2328,6 +2328,11 @@ class libopenmp(Library):
     'kmp_ftn_extra.cpp', 'kmp_version.cpp', 'z_Linux_asm.S',
   ]
 
+  def can_build(self):
+    # OpenMP currently doesn't support Wasm64, see
+    # https://github.com/emscripten-core/emscripten/issues/27221
+    return super().can_build() and not settings.MEMORY64
+
 
 def get_libs_to_link():
   libs_to_link = []