diff --git a/sdks/csharp/src/ISpacetimeDBLogger.cs b/sdks/csharp/src/ISpacetimeDBLogger.cs
index 7678a03265b..8ec7c265f96 100644
--- a/sdks/csharp/src/ISpacetimeDBLogger.cs
+++ b/sdks/csharp/src/ISpacetimeDBLogger.cs
@@ -1,4 +1,7 @@
 using System;
+#if UNITY_5_3_OR_NEWER
+using UnityEngine;
+#endif
 
 namespace SpacetimeDB
 {
@@ -25,6 +28,21 @@ public static class Log
             new ConsoleLogger();
 #endif
 
+        /// <summary>
+        /// Resets the static instance to prevent data persistence when Enter Play Mode Options (Disable Domain Reloading) is active.
+        /// RuntimeInitializeOnLoadMethod is used since it is supported in older versions of Unity.
+        /// AutoStaticsCleanup and NoAutoStaticsCleanup is only supported in Unity 6+
+        /// </summary>
+        /// <remarks>
+        /// See the <see href="https://docs.unity3d.com/6000.5/Documentation/Manual/domain-reloading.html">Unity Domain Reloading Manual</see> 
+        /// and the <see href="https://docs.unity3d.com/6000.5/Documentation/ScriptReference/RuntimeInitializeOnLoadMethodAttribute.html">RuntimeInitializeOnLoadMethodAttribute API Docs</see> for details.
+        /// </remarks>
+        [RuntimeInitializeOnLoadMethod(RuntimeInitializeLoadType.SubsystemRegistration)]
+        private static void ResetStaticFields()
+        {
+            Current = new UnityDebugLogger();
+        }
+
         public static void Debug(string message) => Current.Debug(message);
         public static void Trace(string message) => Current.Trace(message);
         public static void Info(string message) => Current.Info(message);
diff --git a/sdks/csharp/src/SpacetimeDBClient.cs b/sdks/csharp/src/SpacetimeDBClient.cs
index ef202ed168b..3b44aed478d 100644
--- a/sdks/csharp/src/SpacetimeDBClient.cs
+++ b/sdks/csharp/src/SpacetimeDBClient.cs
@@ -6,6 +6,9 @@
 using System.Linq;
 using System.Threading;
 using System.Threading.Tasks;
+#if UNITY_5_3_OR_NEWER
+using UnityEngine;
+#endif
 using SpacetimeDB.BSATN;
 using SpacetimeDB.ClientApi;
 using Thread = System.Threading.Thread;
@@ -289,6 +292,21 @@ internal struct ParsedMessage
 
         private static readonly Status Committed = new Status.Committed(default);
 
+        /// <summary>
+        /// Resets the static instance to prevent data persistence when Enter Play Mode Options (Disable Domain Reloading) is active.
+        /// RuntimeInitializeOnLoadMethod is used since it is supported in older versions of Unity.
+        /// AutoStaticsCleanup and NoAutoStaticsCleanup is only supported in Unity 6+
+        /// </summary>
+        /// <remarks>
+        /// See the <see href="https://docs.unity3d.com/6000.5/Documentation/Manual/domain-reloading.html">Unity Domain Reloading Manual</see> 
+        /// and the <see href="https://docs.unity3d.com/6000.5/Documentation/ScriptReference/RuntimeInitializeOnLoadMethodAttribute.html">RuntimeInitializeOnLoadMethodAttribute API Docs</see> for details.
+        /// </remarks>
+        [RuntimeInitializeOnLoadMethod(RuntimeInitializeLoadType.SubsystemRegistration)]
+        private static void ResetStaticFields()
+        {
+            IsTesting = false;
+        }
+
         /// <summary>
         /// Get a description of a message suitable for storing in the tracker metadata.
         /// </summary>
diff --git a/sdks/csharp/src/SpacetimeDBNetworkManager.cs b/sdks/csharp/src/SpacetimeDBNetworkManager.cs
index 379bf63d86b..5fa50211481 100644
--- a/sdks/csharp/src/SpacetimeDBNetworkManager.cs
+++ b/sdks/csharp/src/SpacetimeDBNetworkManager.cs
@@ -12,6 +12,21 @@ public class SpacetimeDBNetworkManager : MonoBehaviour
     {
         internal static SpacetimeDBNetworkManager? _instance;
 
+        /// <summary>
+        /// Resets the static instance to prevent data persistence when Enter Play Mode Options (Disable Domain Reloading) is active.
+        /// RuntimeInitializeOnLoadMethod is used since it is supported in older versions of Unity.
+        /// AutoStaticsCleanup and NoAutoStaticsCleanup is only supported in Unity 6+
+        /// </summary>
+        /// <remarks>
+        /// See the <see href="https://docs.unity3d.com/6000.5/Documentation/Manual/domain-reloading.html">Unity Domain Reloading Manual</see> 
+        /// and the <see href="https://docs.unity3d.com/6000.5/Documentation/ScriptReference/RuntimeInitializeOnLoadMethodAttribute.html">RuntimeInitializeOnLoadMethodAttribute API Docs</see> for details.
+        /// </remarks>
+        [RuntimeInitializeOnLoadMethod(RuntimeInitializeLoadType.SubsystemRegistration)]
+        private static void ResetStaticFields()
+        {
+            _instance = null;
+        }
+
         public void Awake()
         {
             // Ensure that users don't create several SpacetimeDBNetworkManager instances.
diff --git a/sdks/csharp/src/Table.cs b/sdks/csharp/src/Table.cs
index 609444815d5..c164b8ff985 100644
--- a/sdks/csharp/src/Table.cs
+++ b/sdks/csharp/src/Table.cs
@@ -4,6 +4,9 @@
 using System.IO;
 using System.Linq;
 using System.Threading.Tasks;
+#if UNITY_5_3_OR_NEWER
+using UnityEngine;
+#endif
 using SpacetimeDB.BSATN;
 using SpacetimeDB.ClientApi;
 using SpacetimeDB.EventHandling;
@@ -242,6 +245,21 @@ private static IReadWrite<Row> Serializer
             }
         }
 
+        /// <summary>
+        /// Resets the static instance to prevent data persistence when Enter Play Mode Options (Disable Domain Reloading) is active.
+        /// RuntimeInitializeOnLoadMethod is used since it is supported in older versions of Unity.
+        /// AutoStaticsCleanup and NoAutoStaticsCleanup is only supported in Unity 6+
+        /// </summary>
+        /// <remarks>
+        /// See the <see href="https://docs.unity3d.com/6000.5/Documentation/Manual/domain-reloading.html">Unity Domain Reloading Manual</see> 
+        /// and the <see href="https://docs.unity3d.com/6000.5/Documentation/ScriptReference/RuntimeInitializeOnLoadMethodAttribute.html">RuntimeInitializeOnLoadMethodAttribute API Docs</see> for details.
+        /// </remarks>
+        [RuntimeInitializeOnLoadMethod(RuntimeInitializeLoadType.SubsystemRegistration)]
+        private static void ResetStaticFields()
+        {
+            _serializer = null;
+        }
+
         // The function to use for decoding a type value.
         Row DecodeValue(BinaryReader reader) => Serializer.Read(reader);