diff --git a/python/uv/private/lock.bzl b/python/uv/private/lock.bzl
index 84e4cbbc12..ddb60d0006 100644
--- a/python/uv/private/lock.bzl
+++ b/python/uv/private/lock.bzl
@@ -131,7 +131,7 @@ def _up(x, directory, short_path = False):
     elif hasattr(x, "path"):
         x = x.path
 
-    if not directory:
+    if not directory or paths.is_absolute(x):
         return x
 
     prefix = "/".join([".."] * len(directory.split("/")))
diff --git a/tests/uv/lock/lock_tests.bzl b/tests/uv/lock/lock_tests.bzl
index f14d784ebf..f1aee2fdb1 100644
--- a/tests/uv/lock/lock_tests.bzl
+++ b/tests/uv/lock/lock_tests.bzl
@@ -86,6 +86,20 @@ def _test_up(env):
 
 _basic_tests.append(_test_up)
 
+def _test_up_absolute(env):
+    up = lock_testing.up
+    env.expect.that_str(
+        up("/usr/bin/python3", "dev"),
+    ).equals("/usr/bin/python3")
+    env.expect.that_str(
+        up("/usr/bin/python3", "a/b/c"),
+    ).equals("/usr/bin/python3")
+    env.expect.that_str(
+        up("C:/Python312/python.exe", "dev"),
+    ).equals("C:/Python312/python.exe")
+
+_basic_tests.append(_test_up_absolute)
+
 def lock_test_suite(name):
     """The test suite with various lock-related integration tests