diff --git a/src/wp-includes/ms-site.php b/src/wp-includes/ms-site.php
index 342058156be01..4a35f82089e72 100644
--- a/src/wp-includes/ms-site.php
+++ b/src/wp-includes/ms-site.php
@@ -841,6 +841,17 @@ function wp_uninitialize_site( $site_id ) {
 		$wpdb->query( "DROP TABLE IF EXISTS `$table`" ); // phpcs:ignore WordPress.DB.PreparedSQL.InterpolatedNotPrepared
 	}
 
+	/*
+	 * The site's options tables have just been dropped, so clear the caches that would
+	 * otherwise keep serving the deleted site's data. `clean_blog_cache()` is deliberately
+	 * network level only, and `switch_to_blog()` depends on these caches being cleared to
+	 * surface the failure instead of silently continuing.
+	 *
+	 * @since 7.2.0
+	 */
+	wp_cache_delete_multiple( array( 'alloptions', 'notoptions' ), 'options' );
+	wp_cache_delete( 'is_blog_installed' );
+
 	/**
 	 * Filters the upload base directory to delete when the site is deleted.
 	 *
diff --git a/tests/phpunit/tests/multisite/site.php b/tests/phpunit/tests/multisite/site.php
index 0fa6e4581669a..1a537e7cc6f2d 100644
--- a/tests/phpunit/tests/multisite/site.php
+++ b/tests/phpunit/tests/multisite/site.php
@@ -1619,6 +1619,60 @@ public function test_wp_delete_site_cleans_cache() {
 		$this->assertNull( get_site( $site_id ) );
 	}
 
+	/**
+	 * @ticket 29247
+	 */
+	public function test_wp_delete_site_clears_site_option_caches() {
+		$site_id = self::factory()->blog->create();
+
+		switch_to_blog( $site_id );
+		update_option( 'test_option', 'value' );
+		wp_load_alloptions( true );
+		is_blog_installed();
+
+		// The site's caches are now populated.
+		$this->assertIsArray( wp_cache_get( 'alloptions', 'options' ) );
+		$this->assertNotEmpty( wp_cache_get( 'is_blog_installed' ) );
+		restore_current_blog();
+
+		wp_delete_site( $site_id );
+
+		/*
+		 * The site has no tables anymore, so suppress the roles and user switch the same way
+		 * `wp_is_site_initialized()` does.
+		 */
+		remove_action( 'switch_blog', 'wp_switch_roles_and_user', 1 );
+		switch_to_blog( $site_id );
+
+		$this->assertFalse( wp_cache_get( 'alloptions', 'options' ) );
+		$this->assertFalse( wp_cache_get( 'notoptions', 'options' ) );
+		$this->assertFalse( wp_cache_get( 'is_blog_installed' ) );
+
+		restore_current_blog();
+		add_action( 'switch_blog', 'wp_switch_roles_and_user', 1, 2 );
+	}
+
+	/**
+	 * @ticket 29247
+	 */
+	public function test_clean_blog_cache_does_not_clear_option_caches() {
+		$site_id = self::factory()->blog->create();
+
+		switch_to_blog( $site_id );
+		update_option( 'test_option', 'value' );
+		wp_load_alloptions( true );
+
+		$this->assertIsArray( wp_cache_get( 'alloptions', 'options' ) );
+		restore_current_blog();
+
+		clean_blog_cache( $site_id );
+
+		// `clean_blog_cache()` is network level only, per the discussion on the ticket.
+		switch_to_blog( $site_id );
+		$this->assertIsArray( wp_cache_get( 'alloptions', 'options' ) );
+		restore_current_blog();
+	}
+
 	/**
 	 * @ticket 40364
 	 */