diff --git a/api/src/org/labkey/api/util/XmlBeansUtil.java b/api/src/org/labkey/api/util/XmlBeansUtil.java
index a2617bcd752..f26c2c4c252 100644
--- a/api/src/org/labkey/api/util/XmlBeansUtil.java
+++ b/api/src/org/labkey/api/util/XmlBeansUtil.java
@@ -132,6 +132,7 @@ public static void addComment(XmlTokenSource doc, String comment)
     public static final SAXParserFactory SAX_PARSER_FACTORY_ALLOWING_DOCTYPE;
     public static final XMLInputFactory XML_INPUT_FACTORY;
     public static final DocumentBuilderFactory DOCUMENT_BUILDER_FACTORY;
+    public static final DocumentBuilderFactory DOCUMENT_BUILDER_FACTORY_ALLOWING_DOCTYPE;
 
     static
     {
@@ -145,16 +146,9 @@ public static void addComment(XmlTokenSource doc, String comment)
             SAX_PARSER_FACTORY = saxParserFactory(false);
             SAX_PARSER_FACTORY_ALLOWING_DOCTYPE = saxParserFactory(true);
 
-            //noinspection XMLInputFactory
-            DOCUMENT_BUILDER_FACTORY = DocumentBuilderFactory.newInstance();
-            DOCUMENT_BUILDER_FACTORY.setNamespaceAware(true);
-            DOCUMENT_BUILDER_FACTORY.setFeature("http://apache.org/xml/features/disallow-doctype-decl", true);
-            DOCUMENT_BUILDER_FACTORY.setFeature("http://xml.org/sax/features/external-general-entities", false);
-            DOCUMENT_BUILDER_FACTORY.setFeature("http://xml.org/sax/features/external-parameter-entities", false);
-            DOCUMENT_BUILDER_FACTORY.setFeature("http://apache.org/xml/features/nonvalidating/load-external-dtd", false);
-            DOCUMENT_BUILDER_FACTORY.setFeature(XMLConstants.FEATURE_SECURE_PROCESSING, true);
-            DOCUMENT_BUILDER_FACTORY.setXIncludeAware(false);
-            DOCUMENT_BUILDER_FACTORY.setExpandEntityReferences(false);
+            DOCUMENT_BUILDER_FACTORY = documentBuilderFactory(false);
+            // Use the ALLOWING_DOCTYPE variant when parsing XML that contains a <!DOCTYPE> declaration (e.g. NCBI's eSummary responses)
+            DOCUMENT_BUILDER_FACTORY_ALLOWING_DOCTYPE = documentBuilderFactory(true);
         }
         catch (ParserConfigurationException | SAXException e)
         {
@@ -181,4 +175,26 @@ private static SAXParserFactory saxParserFactory(boolean allowDocType) throws SA
         result.setFeature(XMLConstants.FEATURE_SECURE_PROCESSING, true);
         return result;
     }
+
+    private static DocumentBuilderFactory documentBuilderFactory(boolean allowDocType) throws ParserConfigurationException
+    {
+        //noinspection XMLInputFactory
+        DocumentBuilderFactory result = DocumentBuilderFactory.newInstance();
+        result.setNamespaceAware(true);
+
+        // Disable features that could lead to XXE or other vulnerabilities.
+        // When allowDocType is true the DOCTYPE declaration is permitted. External entity
+        // resolution remains disabled, so XXE protection is still in effect.
+        if (!allowDocType)
+        {
+            result.setFeature("http://apache.org/xml/features/disallow-doctype-decl", true);
+        }
+        result.setFeature("http://xml.org/sax/features/external-general-entities", false);
+        result.setFeature("http://xml.org/sax/features/external-parameter-entities", false);
+        result.setFeature("http://apache.org/xml/features/nonvalidating/load-external-dtd", false);
+        result.setFeature(XMLConstants.FEATURE_SECURE_PROCESSING, true);
+        result.setXIncludeAware(false);
+        result.setExpandEntityReferences(false);
+        return result;
+    }
 }